https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308812/
Estudio en UK en 2017
Genetic correlations were examined between male pattern baldness and 24 cognitive, health, and anthropometric traits using LD Score regression. No significant associations were found; all estimates were close to zero (S6 Table).
Discussion
In this large GWAS study of male pattern baldness, we identified 287 independent genetic signals that were linked to differences in the trait, a substantial advance over the previous largest GWAS meta-analysis, which identified eight independent signals [15]. We showed—in line with a previous study [13], but with much greater precision—that a substantial proportion of individual differences in hair loss patterns can be explained by common genetic variants on the autosomes as well as on the X chromosome. However, the variance explained by X chromosome variants is much lower for late-onset compared to early-onset male pattern baldness [13]. Finally, by splitting our cohort into a discovery and a prediction sample, we showed a predictive discrimination (AUC = 0.78) between those with no hair loss and those with severe hair loss.
Despite there being genetic overlap for SNP hits associated with baldness and Parkinson’s Disease—first noted in Li et al. [15] and replicated here—we observed no statistically significant genetic correlations after correcting for multiple testing between baldness and any of the health, cognitive, or anthropometric outcomes we studied. There were very small (maximum absolute genetic correlation of 0.13) but nominally-significant associations with height, bipolar disorder, number of children born, and age at menarche, such that the genes associated with more hair loss were linked to shorter stature, younger age at menarche, fewer offspring, and a lower risk of bipolar disorder (all P<0.05). The local but not global overlap of SNPs associated with baldness and other traits, such as Parkinson's Disease, might be explained by chance due to the large number of hits for baldness, or pleiotropy at single sites with no systemic overlap. The point estimates for the genetic correlations were all near zero, suggesting true null associations as opposed to a lack of statistical power to detect modest-sized correlations.
Conclusion
We identified over two hundred independent, novel genetic correlates of male pattern baldness—an order of magnitude greater than the list of previous genome-wide hits. Our top SNP and gene-based hits were in genes that have previously been associated with hair growth and development. We also generated a polygenic predictor that discriminated between those with no hair loss and those with severe hair loss. Whereas accurate predictions for an individual are still relatively crude, of those with a genetic score in the top 10% of the distribution, 58% reported moderate-to-severe hair loss. The release of genetic data on the full UK Biobank cohort will further refine these predictions and increase our understanding of the genetic architecture of male pattern baldness.
Hay un par mas, pero para hacerlo corto lo resumo:
- A dia de hoy los analisis geneticos apenas dan para predecir con un 78% de acierto si una persona no tiene nada de alopecia o tiene mucha alopecia, un 58% con alopecia leve o moderada, es decir casi impredecible los que van a tener menos caida y alopecia aunque tengan antecedentes geneticos.
- Se saben que hay mas de 200 marcadores geneticos, pero no se sabe nada de correlaciones con otras enfermedades o caracteristicas fisicas, edad, y otros
- Los datos de correlacion de herencia genetica confirman que es genetico
- No se sabe nada aun ni mucho de sus mecanismos ni tampoco correlaciones con la escala Norwood.
Vamos que a dia de hoy basicamente aun se estan buscando que marcadores y genes y caracteristicas geneticas definen a hombres y a ver si es posible determinar patrones de antemano.
No se sabe nada de correlaciones con caracteristicas de los sujetos ni otras condiciones medicas.
Obviamente no se sabe nada de que tipo de patron, tan siquiera si al tener esas caracteristicas geneticas heredadas el paciente va realmente a tener alopecia y mas importante, en que patron.
Ya lo de tener algun tratamiento asociado es pura ciencia ficcion.
Conclusion: es marketing porque como mucho te podran decir si tienes alopecia con un ~70-80% de acierto, algo que con una lupa si tienes miniaturizacion y con una simple pregunta de tus antecendentes familiares basta, no hay tratamientos que cambien en funcion de un analisis genetico, y los tratamientos geneticos no solo de alopecia sino de cualquier enfermedad son pura ciencia ficcion a decadas de poderse realizar. Han identificado 200 y pico genes, de los cuales solo un 58% son distinguibles en la mayoria de patrones, que cada uno saque sus conclusiones.
Esto es ciencia novel actual y fiable. Lo mas importante es que HAY CORRELACION CERO con caracteristicas fisicas o enfermedades/condiciones de pacientes, ya me diras para que sirve, no hay "personalizacion" posible con el estado del arte actual, por lo tanto la realidad es que da un poco igual tus caracteristicas geneticas, y saber si tienes AGA y miniaturizacion se ve con una lupa y si tienes probabilidad de ser calvo pues con unas fotos de tus padre, tios y abuelos maternos y paternos basta.
La realidad es que hoy en dia la ciencia genetica apenas da y estan aun en esta fase de saber relacionar y predecir cuanta probabilidad hay de quedarse calvo, cada nuevo estudio sacan nuevos marcadores, pero todo lo que sea asociar con caracteristicas y ya no digamos personalizar tratamientos no esta establecido.
por suerte a los 3 meses me mandaron un pote que ponía minoxidil en la etiqueta, les pille con el carrito del helado y volví a mi dermatologa.
