[txemitooo]

Pues estoy bastante recuperado del finas nunca se sabe a que nivel, pero soy una persona normal similar a la que era antes del finas, puedo pensar con claridad etc etc...

[waynerooney]

hola! tenia una pregunta y era q si este producto se puede usar con otro vehículo que no sea PG ?¿ ,esq tengo dermatitis y me la agrava. gracias

Hola el cb en forma de sal que es la que vende kane yo me la he preparado con etanol agua desionizada y en vez de ppg glicerina, de todas formas puedes mezclarlo en etanol y agua des ionizada, al ser en sal incluso podrías disolverlo en cualquier loción hidroalcolica anticaida...

uso el dualgen15% que va en base de etanol y glicerina podria mezclarlo ahí por ejemplo??
gracias.

[feder]

Es bueno saberlo, cuanto tiempo te llevo ese proceso de mejoria y con que tratamiento?

Y por otro lado, que tratamiento usas hoy en dia para la aga, el cb??

SALUDOS

[luca10]

Hola a todos, un chico de un foro ingles a publicado como preparar la solución de cb. Creen que pueda servir? y si seria fácil conseguir esto en argentina.

Hey guys, so as promised here's a proposed vehicle for CB-03-01:

1) Ceteareth-20 (5%): is a penetration enhancer which alters the skin structure, allowing substances to penetrate deeper into the skin. It will help CB dissolve better and stay in the vehicle during storage.

2) Oleyl alcohol (10%): either of these will do as the solvent/emulsion stabiliser. I did a bit of reading on CB-03-01 properties and it seems to definitely be soluble in DMSO. DMSO is not a good solvent for long-term use and has had some possible deaths associated with its use! So after digging around a bit I thought either of these should be a decent replacement. Has anyone been able to dissolve CB in alcohol? Plz let me know asap...thx

3) Dimethicone 200 (5%): keeps the skin moist and improves absorption. A lot of topicals have this added to ensure optimal absorption.

4) Glyceryl monostearate (2%): should help CB dissolve in alcohol and will also act as a preservative.

5) Methyl Hydroxybenzoate (2%): is also a common preservative added. We wanna make sure these expensive batches have long enough shelf expiry.

6) Phenoxyethanol (2%): is also a preservative with bacteriostatic properties. It is generally combined with methyl hydroxybenzoate to provide a broad bacteriostatic protection againsts a range of microbes.

7) Propyl Hydroxybenzoate (2%): is another preservative used against fungal growth.

Stearyl alcohol (5%): this is not a must but may help with absorption.

9) Sodium hydroxide (2%): this is a chemical buffer to adjust the pH to around 5.5 (skin pH). This way our lotion wont sting when we apply it.

10) Emu oil (to 100mL): this is simply to increase absorption deep into the dermal layer! And is a great substitute for mineral oils which seems to be bad for hair

11) CB-03-01: (1-2%)

__________________________________________________ _____________

Preparation:

Step 1. Dissolve CB-03-01 in Oleyl alcohol.

Step 2. Add Ceteareth-20 and Stearyl alcohol. Stir until all powder is dissolved.

Step 3. Add the remaining ingredients.




Gracias!!!

[wolframio]

Muy buen avance luca10

Creo que han enviado esta información a kane y posiblemente la estudiarán para ver como de efectivo puede ser este vehiculo.

[feder]

News??

[kikospain]

Que se sabe de esto chavales ???
Tienen exito los que lo estan usando o ni dios experimenta ... ¿?

Por cierto he comprado un gramo de cb y he comprado via ebay tambien aceite de emu puro y n-methyl 2 pyrrolidone ya que decian que era el vehiculo idoneo para el cb , cual es mi sorpresa que le añado minoxidil y otros polvos y no disuelve ni de coña.
No se si lo ideal o es pillar propilenglicol o alcohol oleico y disolver el cb en esto y luego si añadirle el methyl pyrrolidone para la penetracion ,porque si por ejemplo lo mezclo con aceite de emu queda como pintura blanca ¿? en fin ...

[pelimorfo]

yo estoy planteandome usar el cb, hay alguien que lo este usando con exito?

[pelimorfo]

y donde se consigue ahora el CB? en kane shop, parece que ya no esta.

[luca10]

Si alguien entiende ingles y le interesa meterse mas en el tema acá hay mas info.

Desmond dice:
Tenemos un vehículo para CB-03-01: VersaPro.
Hey guys, sorry for not being here as often as I used to. Been busy doing a whole bunch of exciting stuff. So here's what I've been up to.

Around 6 months ago, when I got back from Korea, our company suddenly underwent new management and decided to provide compounding services at some of their larger Pharmacies and lucky enough, our Pharmacy was on that list.

For those not familiar with medical terms, "compounding" is when a Pharmacy prepares a medicinal product on site. Most of these are pessaries and creams but can include tablets, capsules, suppositories, lotions etc etc.

Anyways, long story short, I put my hand up to get the training which went on for a month and came across some amazing formulations and vehicles along the way. The whole time I was thinking about how many options we have at our fingertips to use as a vehicle for CB-03-01. We just didn't know about it.

And here's the interesting part, when we did the 'topical preparation' session, a particular vehicle kept on being mentioned called "Versapro" by a company called Medisca.

With its great carrying capacity and excellent emollient characteristics, MEDISCA’s VersaPro™ Cream Base is ideal for both pharmaceutical and cosmetic purposes. Its versatility relates in part to its increased pH stability and excellent compatibility with a wide range of active pharmaceutical ingredients. This unique oil-in-water emulsion is non-greasy, non-irritant and paraben-free. VersaPro™ is a highly moisturising cream formulated with excellent penetrating properties.
The studies they showed us involved using Versapro as a vehicle for Progesterone and it beat all other competitor's in terms of dosage delivered by a mile! I've attached these studies below for you to see. Not only that, it has crazy properties. As long as your active pharmaceutical ingredient (API) is a salt it is able to carry deep into the dermal layer. It has amazing penetrating properties and is ideal for steroidal and hormonal therapies. Ironically, CB-03-01 is in salt form and a steroid.

The results speak for themselves. Check it out:





Here's also the study testing its penetration properties using a steroidal active ingredient (Hydrocortisone).

http://conservancy.umn.edu/bitstream...AC0?sequence=1

So anyways, after I came across all of this mind blowing information, I sat down with our lecturer and told him about the properties of CB-03-01 (molecular weight, pKa, pH, its salt form, etc) and he was pretty certain Versapro would get it where it needs to go (dermal layer). I'm also pretty sure it will be sufficient.

The lecturer also always pointed out, if you're not sure which one will do the job, most probably Versapro will! It's a no-brainer. Anyways guys that's all I gathered over the last few months of training. Hope it's been useful.

Oh also, any compounding chemist in Australia and USA can order this 'base' in for you. We have been ordering a ton in over the last month and it's cheap as chips. We get a 100g jar for about $20. All you need to do is weigh 2g of CB and mix it into it and your good to go. With regards to its consistency, it is definitely something you wanna apply overnight and wash off in the morning.

Good luck my brothers and please post any questions that you may have. I'll try my best to answer your questions.

Cheers.

It's interesting to note, Cosmo was showing efficacy by comparing CB-03-01 to Progesterone administered topically. We now have sufficient data that this vehicle is capable of getting Progesterone to the dermal layer and has all the ticks for carrying a drug with properties matching Cb-03-01.

Here's Medisca's webpage btw. Looks like they are also based in Canada which is excellent

http://www.medisca.com/en-us/LandingPage.aspx

In Pharmacy we use the 'Doubling method' to add a powder into a cream. This video is a perfect tutorial for those wanting to give this a shot. This method ensures, the powder is evenly distributed into the cream.


https://www.youtube.com/watch?v=vFkcAJBGXek

[luca10]

Lo que me gusta de esto es que puede podría curar la seborrea también.

CB-03-01, a molecule patented by Cosmo, is a steroidal ester, androgen antagonist derived from 11-deoxycortisone, which tightly mimics the profile of an ideal anti-androgen for topical use.
The objective is to create a product for topical application to treat acne, male pattern baldness, and seborrhoea that does not have the side effects of products currently being taken in tablet form.

[caiu]

Muy buena noticia, luca10!

[hertito]

Muy buenas a todos, esto parece una muy buena noticia… alguien ha venido usando el cb?? Cuanto cuesta el gramo? Yo creo que me voy a animar aprobarlo, a ver si averiguamos como conseguir esa misma crema.
Un saludo

[kikospain]

Al fin una noticia buena... si esto funciona preparaos para ver regeneracion , si penetra hasta dentro del foliculo que es algo que yo hasta que no lo vea no lo creo

De todos modos se sabe la preparacion , osea se disuelve una cantidad de cb en este vehiculo de medisca , 1ml por ej. y ya esta ?? asi de simple ??? Si es asi me gustaria comprar el compuesto lo antes posible si se puede

Yo compre cb en kaneshop y lo vengo disolviendo en aceite de emu y glicerol , pero sin resultado.Ahora no se si vende cb o no porque en su pagina solo aparece el clasico RU y peptidos de cobre y ya se puede pagar por paypal.Yo en su momento page por western union

[hertito]

Se supone que si kikospain…mezclar el cb con la crema y ya esta. Cuanto tecosto el gramo? Yo quiero comprar 3 gramos y dos botes de crema para usarla al 1,5%. También quiero investigar como conseguir la crema versapro…