[Rayista]

Hola,

Muchos de los productos que van a salir nuevos o se supone que saldrán, así como otras cosas que comenta la gente parecen bastante complicadas de conseguir y sobre todo peligrosas, pero creo que este no va a ser el caso.

He encontrado este tema en el foro de hairlosstalk y me he puesto a buscar el artículo original, porque solo aparecía el enlace a un pequeño resumen del mismo. Os lo dejo por si alguien lo ve viable, de todas formas voy a repasarlo de nuevo y os comentaré mis impresiones, lo único que yo de química nada de nada...

El artículo completo está en formato pdf, son solo diez páginas pero están escritas en inglés.

https://www.jstage.jst.go.jp/article/bp ... 00528/_pdf

Saludos

[Rayista]

Ya se llevó a cabo el estudio y los ensayos con personas, y además se publicó otro artículo sobre ello a finales de 2015:

https://www.jstage.jst.go.jp/article/bp ... 00387/_pdf

Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial:

We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety
and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia.
Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental
group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the
control group received a dermal application of placebo. Changes in hair count, diameter, and density were
evaluated with a Folliscope. Patient satisfaction was evaluated via questionnaire and clinical photographs
were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair
diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also con-
firmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE
were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals.

[Rayista]

In previous research, rice bran supercritical CO2 extract (RB-SCE) was found to be a potent inducer of hair growth
in mice via 5-alpha-reductase inhibition.

In addition, the toxicological safety of RB-SCE was investigated using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay in RAW264.7
cells. Further safety evaluations included single oral dose toxicity in rats, an acute dermal and ocular irritation test, a
single dose and 4-week repeated dose dermal toxicity study, and a genotoxicity assessment.

Thus, RB-SCE is thought to be safe. Despite its therapeutic potential and safety, no reports have described a clinical study of RB-SCE for alopecia. Therefore, in the present study, we evaluated the safety of RB-SCE and its effects on markers of hair growth in alopecia.
We expect that the results of this open-label trial can provide basic clinical information regarding changes in biochemical
markers after RB-SCE treatment.
Previous researchers have confirmed the toxicological safety of RB-SCE in RAW264.7 cells. Additional safety evaluations included single oral dose toxicity in rats, an acute dermal and ocular irritation test, a single dose and 4-week
repeated dose dermal toxicity study, and a genotoxicity assessment.

As urinalysis, hematological tests, clinical biochemistry tests, necropsies, and histopathological examinations were performed in male and female rats after 4-week repeated-dose dermal administration of RB-SCE, no liver or
kidney damage was observed.

In addition, in this study, no specific side effects such as irritant contact dermatitis, allergic contact dermatitis, itching, pricking, burning, erythema, oozing, vesicles, skin rashes, and so on were observed in patients
receiving RB-SCE. Therefore, RB-SCE is thought to be safe
for topical application in humans.
However, the limitations of this study are the single-center
study design, small number of subjects, and lack of blood
chemistry research including hormonal levels, extensive interviews with patients about hormonal effects detected by sexual dysfunction (e.g., loss of libido), and confirmation of the absence of liver or kidney damage. Further studies, including multicenter studies with longer treatment periods, larger sample-size patient populations, blood chemistry research, and extensive patient interviews, are needed to confirm the present results.

https://www.researchgate.net/profile/Jae_Suk_Choi

[lokd]

Algún resumen en castellano? He leído algo de que inhibe la alfa5, igual que el finas, y por tanto, a no ser que sea simplemente en los folículos no veo la novedad.

[Modill]

Es interesante, infórmanos más rayista.