[cheriff]

No es que os quiera desanimar ni mucho menos, hoy he estado hablando con un farmaceutico amiguete mio; me he comprado el tan famoso Ketoconazol, más que nada para probarlo; le he dicho que por el foro lo asemejan a la acción del Minox 2 y otras cosas que se dicen por estos lares.
Su respuesta ha sido tajante:
Es una tontería! No es más que un fungicida.

A mí me ha recomendado que únicamente lo use una vez a la semana a lo sumo. Ya os contaré. Un saludo, y que nadie se ofenda.

[Nico]

Hola como estas !

Cuando puedas pasale esto para leer, por ahi no sabe bien para que puede funcionar el ketoocnazol 2%.

Acá te dejo un estudio donde explica como funciona en casos de alopecia androgenética:

It can reasonably be concluded that the clinical efficacy of ketoconazole shampoo in the treatment of AGA is primarily a function of DHT pathway disruption rather than an anti-inflammatory effect. In rat studies ketoconazole caused 5-R inhibition [28]. Furthermore, in humans ketoconazole has also been shown to inhibit the binding of 5-R to sex hormone globulins [29]. These clinical studies suggest that ketoconazole like finasteride may inhibit the production of DHT. Unlike finasteride ketoconazole has been shown to bind to human AR [30]. Thus, the effect of ketoconazole on the DHT pathway may be two-fold: inhibition of DHT and/or inhibition of DHT binding to AR. Either or both of these properties would result in reduced incidence of DHT binding to AR and inhibiting the pathway that leads to the miniaturizing of hair follicles.

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA.

Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.

PMID: 14729013 [PubMed - indexed for MEDLINE]

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

Saludos !!

[cheriff]

Hola nico, ya lo había leido anteriormente y ya sabía como funcionaba el Gel.
Te comento tras haber usado mi primera aplicación:
Generalmente uso el champú Naturaleza y Vida anticaida (os lo recomiendo encarecidamente).
Tras aplacarme el gel, masajear el cuero cabelludo, dejarlo 5 minutos y aclararme con abundante agua, debo decir que no me ha dejado del todo mal el pelo. Al menos creo que el efecto sheddin que quedaba por usar el minox ha desaparecido. También os digo que he sido un poquito previsor y viendo como decían algunos foreros que dejaba el pelo reseco, tras lavar el pelo y con éste húmedo, lo he rociado un par de veces con el pulverizador con Keratina líquida (Anian, del mercadona -3 euros-). Me da que la combinación de Keto+Keratina (tampoco abuseis de ella, un par de pulverizaciones y ya) me ha dejado el pelo simplemente cojonudo ( y eso que ya llevo dos aplicaciones de Minox, desde que empecé el tratamiento, es la primera vez que veo el pelo tan sanote y que no parece un estropajo). En fín, he aquí mi primera experiencia, quizá no sea un timo, pero los que no lo necesiteis para lo que realmente sirve el gel (seborrea y las costritas que salen a algunos), en verdad con que lo useis una vez en semana os sobra. Saludos.

[nacho182]

De todas formas, el Ketoconazol al 2% es un complemento al tratamiento primario, llamese minoxidil y/o finasteride.

Tu farmacéutico puede opinar lo que quiera, el tema es que hay pruebas fehacientes respecto a la efectividad del ketoconazol con la AGA. Que te funcione o no, será cuestión de tu organismo.

[eltiolavara]

tal y como estan las cosas yo no me fiaria de los farmaceuticos ya que al igual que muchos medicos no tienen ni idea,y me refiero a que saben solo lo justo de los tratamientos y enfermedades a no ser que tenga una vocacion muy especial por su trabajo e investigue por su cuenta.
de ejemplo te pongo el finasteride: unos dicen que su uso es continuo de por vida,otros que hay que descansar,unos que hay que tomarlo a diario,otros te mandan los 5mg cada 2-3 dias,unos que no hay efectos secundarios,otros que si,unos que lo interrumpas cuando quieras tener hijos,otros que da igual,etc.......
Y sin ir mas lo que m paso el otro dia respecto a los farmaceuticos que ya existiendo finasteride actavis 1mg en españa no tienen ni idea de su existencia y algunos incluso lo niegan.......vaya poca profesionalidad en ambos casos.