[dav110]

Hola, una pregunta, me recomendasteis hace un tiempo k usase un champu con ketoconazol al 2% y efectivamente asi lo estoy haciendo, un par de veces por semana, pero he leido en algunos posts que puerdes ponertelo 3 veces por semana, k tambien va muy bien, por que como es un antiandrogenico suave tres veces mejor que dos. Que opinais? yo hasta entonces me lo pongo dos y si es mejor tres, pero claro..haber si por pasarme desarreglo otra cosa, jajaja Un saludo

[Olivia]

Hola Dav, en realidad el shampoo con Keto no se usa más de tres veces por semana porque es muy fuerte, además no es necesario como tratamiento. Yo, te recomendaría que lo uses solo 2 veces y cada tanto 3. Como lo vienes haciendo hasta ahora está perfecto. No te olvides de dejarlo actuar de 4 a 5 minutos en cada lavado

Saludos

[Juan Cuesta]

Como antiandrógeno pues no creo q incrementar la frecuencia de lavado haga más efecto... 3 x semana tal vez si tuvieras un episodio severo de dermatitis seborreica pero sólo hasta q remitan los síntomas.

Sigue con 2 x semana q así está bien.

[gonzalete]

estoy con juan cuesta


se usa 3 veces cuando ok tienes es DS(dermatitis seborreica) y luego solo 2 veces para controlarla por tanto si lo tuyo es AGA usalo solo 2 veces,pues es muy fuerte para usarlo mas veces.

un saudo

[garri2]

Yo no se si por aqui alguien sera dermatologo, pero hay cosas que decis que no me cuadran,en el prospecto del champu/gel pone bien claro que hay que usarlo 2 veces por semana, durante 2/4 semanas y que no debe sobrepasarse la dosis , ni la duracion del tratamiento , que por cierto es un mes.Lo digo porque hay gente por aqui, que te lo recomienda tres veces por semana y que lo uses todo el tiempo que quieras, cuando eso no va asi,insisto no se cuantos años de dermatologia tendra la gente por aqui, para colocarte un champo bastante fuerte, que si te pasas te puede hacer mas daño que beneficio, para el resto de tu vida y encima tres veces por semana.De hecho mi dermatologo me dijo que lo usara solo 1 vez por semana, que como me pasara me quedaria pelon.Saludos.

[difuso]

Yo creo que es como cualquier medicación, se supone que en 2-4 semanas se te ha resuelto el problema, y si no...? pues a seguir con el tratamiento, pasa con los antidepresivos, con los ansioliticos y con todo. No creo que te vayas a quedar calvo por usar un champú dos veces por semana, ni que fuera ácido sulfúrico
saludos

[Nico]

Hola como estan !!!

Aca dejo unos estudios en Ingles para el que le intereza :

Estimado Paul: yo recomiendo el uso de Ketoconazol para todos aquellos que tengan AGA y por supuesto, mientras no les "re-contra" seque el cuero cabelludo. Ni hablar si tenés seborrea, lo usaría sí o sí.
¿Sabés un poco de Inglés? Acá tenés diferentes estudios que demuestran su efectividad para tratar la AGA.

It can reasonably be concluded that the clinical efficacy of ketoconazole shampoo in the treatment of AGA is primarily a function of DHT pathway disruption rather than an anti-inflammatory effect. In rat studies ketoconazole caused 5-R inhibition [28]. Furthermore, in humans ketoconazole has also been shown to inhibit the binding of 5-R to sex hormone globulins [29]. These clinical studies suggest that ketoconazole like finasteride may inhibit the production of DHT. Unlike finasteride ketoconazole has been shown to bind to human AR [30]. Thus, the effect of ketoconazole on the DHT pathway may be two-fold: inhibition of DHT and/or inhibition of DHT binding to AR. Either or both of these properties would result in reduced incidence of DHT binding to AR and inhibiting the pathway that leads to the miniaturizing of hair follicles.

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA.

Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.

PMID: 14729013 [PubMed - indexed for MEDLINE]

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

Un abrazo!

Saludos !!!