[mustang]

https://www.leoandlongevity.com/post/th ... inasteride

Punziones cerebrales que demuestra la ausencia parcial o completa de Allopregnenolona en pacientes que dejaron Finasteride. Tambien las posibles soluciones

Muy interesante

[MrShelby]

https://www.leoandlongevity.com/post/th ... inasteride

Punziones cerebrales que demuestra la ausencia parcial o completa de Allopregnenolona en pacientes que dejaron Finasteride. Tambien las posibles soluciones

Muy interesante

Podrías resumir lo que dice para los que no controlamos de inglés y de todos esos tecnicismos? gracias.

[mustang]

The physiological basis of mood disorders caused by 5αRIs has been associated with the dysregulation of neurosteroids and androgen deficiency [16,17]. Neurosteroids, along with their derivatives, are steroids active in the brain and include allopregnanolone, dihydrodeoxycorticosterone, dehydroepiandrosterone, and pregnenolone [18]. It has been postulated that neurosteroids have anxiolytic, antidepressant, and memory enhancement properties and play a role in neuroprotection [19,20]. As 5αRIs inhibit the enzyme 5-alpha-reductase required to synthesize these neurosteroids, the resulting decrease in the neurosteroid biosynthesis could contribute to psychiatric adverse events. Reduction in allopregnanolone is associated with depressive symptoms and unipolar major depression in men [16,17,21]. Although finasteride and dutasteride were shown to inhibit allopregnanolone in animal models, there is no information in humans [22,23]. Other possible mechanisms involve reduction in levels of DHT. A study by Barrett-Connor et al. [24 ]showed that BDI survey scores for measuring depression were inversely associated with bioavailable DHT levels and genetic predisposition. Two polymorphisms (CAG) rs4045402 and (GGN) rs3138869 in the gene encoding for the androgen receptor have been hypothesized to play a role in finasteride sensitivity [25].

Salvo las punciones realizadas en Italia, donde no se encontraron neuroesteroides presentes en liquido cefalorraquideo.

[mustang]

The physiological basis of mood disorders caused by 5αRIs has been associated with the dysregulation of neurosteroids and androgen deficiency [16,17]. Neurosteroids, along with their derivatives, are steroids active in the brain and include allopregnanolone, dihydrodeoxycorticosterone, dehydroepiandrosterone, and pregnenolone [18]. It has been postulated that neurosteroids have anxiolytic, antidepressant, and memory enhancement properties and play a role in neuroprotection [19,20]. As 5αRIs inhibit the enzyme 5-alpha-reductase required to synthesize these neurosteroids, the resulting decrease in the neurosteroid biosynthesis could contribute to psychiatric adverse events. Reduction in allopregnanolone is associated with depressive symptoms and unipolar major depression in men [16,17,21]. Although finasteride and dutasteride were shown to inhibit allopregnanolone in animal models, there is no information in humans [22,23]. Other possible mechanisms involve reduction in levels of DHT. A study by Barrett-Connor et al. [24 ]showed that BDI survey scores for measuring depression were inversely associated with bioavailable DHT levels and genetic predisposition. Two polymorphisms (CAG) rs4045402 and (GGN) rs3138869 in the gene encoding for the androgen receptor have been hypothesized to play a role in finasteride sensitivity [25].

Salvo las punciones realizadas en Italia, donde no se encontraron neuroesteroides presentes en liquido cefalorraquideo.

[ElCigala]

Estaria genial algún estudio que confirmara si suplementando con DHEA o pregnanolona se puede mejorar